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Article

Spatial progression and molecular heterogeneity of IDH-mutant glioblastoma determined by DNA methylation-based mapping.

Acta neuropathologica communications - 30 Jun 2021

Lyon James F, Vasudevaraja Varshini, Mirchia Kanish, Walker Jamie M, Corona Robert J, Chin Lawrence S, Tran Ivy, Snuderl Matija, Richardson Timothy E, Viapiano Mariano S

Abstract excerpt

Glioblastoma (GBM) is the most common malignant primary central nervous system (CNS) neoplasm in adults, and has an almost universally poor prognosis. Recently, an emphasis on genetic and epigenetic profiling has revealed a number of molecular features useful in the diagnostic and prognostic classification of GBM, advancing our understanding of the underlying features that make these tumors so aggressive and...

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Source

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Identifiers

PMID: 34193272
DOI: 10.1186/s40478-021-01221-7
PMCID: PMC8243907

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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