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Loss of DIP2C in RKO cells stimulates changes in DNA methylation and epithelial-mesenchymal transition

17 Jul 2017

Abstract excerpt

BACKGROUND: The disco-interacting protein 2 homolog C (DIP2C) gene is an uncharacterized gene found mutated in a subset of breast and lung cancers. To understand the role of DIP2C in tumour development we studied the gene in human cancer cells. METHODS: We engineered human DIP2C knockout cells by genome editing in cancer cells. The growth properties of the engineered cells were characterised and transcriptome and...

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PMID: 28716088
DOI: 10.1186/s12885-017-3472-5

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