Article
Differential Mitochondrial Requirements for Radially and Non-radially Migrating Cortical Neurons: Implications for Mitochondrial Disorders.
Cell reports - 12 Apr 2016
Lin-Hendel Erika G, McManus Meagan J, Wallace Douglas C, Anderson Stewart A, Golden Jeffrey A
Abstract excerpt
Mitochondrial dysfunction has been increasingly linked to neurodevelopmental disorders such as intellectual disability, childhood epilepsy, and autism spectrum disorder, conditions also associated with cortical GABAergic interneuron dysfunction. Although interneurons have some of the highest metabolic demands in the postnatal brain, the importance of mitochondria during interneuron development is unknown. We find...
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