Article

Structural insights into conformational stability of ESR1 and structure base screening of new potent inhibitor for the treatment of Breast Cancer

2022-04-06

Abstract excerpt

<title>Abstract</title> <p>Estrogen receptor alpha (ERα), a nuclear receptor protein encoded by the estrogen receptor1 (ESR1) gene, is an important biomarker in breast cancer diagnosis. Any dysregulation in its expression can actively implicate the development and progression of the disease. ERα is abnormally expressed in around 60% of the active cases, making it an important therapeutic target. In this study, we...

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Literature Corpus work: f6377881-fc76-5139-b999-34710a204a1c
DOI: 10.21203/rs.3.rs-1413803/v2

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