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[Effect of ESR1 Somatic Mutations on SERM/SERD Binding: Insights from Molecular Docking and Molecular Dynamics Simulations].

Molekuliarnaia biologiia - 1 Jan 2026

Margatskiy I V, Eliseikin A M, Artemov V E, Ponkratenko I O, Studennikov A E, Glushkov A N

Abstract excerpt

Acquired resistance to endocrine therapy poses a major limitation in the treatment of estrogen receptor (ER)-positive breast cancer (BC). Somatic mutations of the ESR1 gene, which encodes ERα, are one of the key resistance mechanisms. However, the effect of mutations and especially double mutations on the binding of novel drugs remains insufficiently understood. To evaluate the effect of the mutations at the...

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Identifiers

PMID: 42599237
DOI: 10.7868/S3034555326030107

Genes

ESR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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[Effect of ESR1 Somatic Mutations on SERM/SERD Binding: Insights from Molecular Docking and Molecular Dynamics Simulations].PMID 42599237Read ↗

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Targeting Unique Ligand Binding Domain Structural Features Downregulates DKK1 in Y537S ESR1 Mutant Breast Cancer CellsSemantic proximity Read ↗

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cellsSemantic proximity Read ↗

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