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Article

Personalized prediction of EGFR mutation-induced drug resistance in lung cancer.

Scientific reports - 4 Oct 2013

Wang Debby D, Zhou Weiqiang, Yan Hong, Wong Maria, Lee Victor

Abstract excerpt

EGFR mutation-induced drug resistance has significantly impaired the potency of small molecule tyrosine kinase inhibitors in lung cancer treatment. Computational approaches can provide powerful and efficient techniques in the investigation of drug resistance. In our work, the EGFR mutation feature is characterized by the energy components of binding free energy (concerning the mutant-inhibitor complex), and we...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 24092472
DOI: 10.1038/srep02855
PMCID: PMC3790204

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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