Article

Prediction and design of transcriptional repressor domains with large-scale mutational scans and deep learning

2024-09-24

Abstract excerpt

Regulatory proteins have evolved diverse repressor domains (RDs) to enable precise context-specific repression of transcription. However, our understanding of how sequence variation impacts the functional activity of RDs is limited. To address this gap, we generated a high-throughput mutational scanning dataset measuring the repressor activity of 115,000 variant sequences spanning more than 50 RDs in human cells....

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Identifiers and source

Literature Corpus work: 715bf22a-de84-5524-8857-0a7e48ad1979
DOI: 10.1101/2024.09.21.614253

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