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Article

Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma.

Clinical and translational medicine - 1 Jun 2021

Tian Jianbo, Lu Zequn, Niu Siyuan, Zhang Shanshan, Ying Pingting, Wang Lu, Zhang Ming, Cai Yimin, Dong Tianyi, Zhu Ying, Zhong Rong, Wang Zhihua, Chang Jiang, Miao Xiaoping

Abstract excerpt

BACKGROUND: Esophageal squamous cell carcinoma (ESCC) is one of the common gastrointestinal malignancy with an inferior prognosis outcome. DNA replication licensing aberration induced by dysregulation of minichromosome maintenance proteins (MCMs) causes genomic instability and cancer metastasis. SUMOylation modification plays a pivotal role in regulation of genomic integrity, while its dysregulation fueled by...

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Identifiers

PMID: 34185429
DOI: 10.1002/ctm2.485
PMCID: PMC8236122

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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