Article
Targeted next generation sequencing identified clinically actionable mutations in patients with esophageal sarcomatoid carcinoma.
BMC cancer - 5 Mar 2018
Lu Hongyang, Yang Shifeng, Zhu Huineng, Tong Xiaoling, Xie Fajun, Qin Jing, Han Na, Wu Xue, Fan Yun, Shao Yang W, Mao Weimin
Abstract excerpt
BACKGROUND: Esophageal sarcomatoid carcinoma (ESC) is a rare disease with a mixture of both carcinomatous and sarcomatous components in the tumor. Its genetic background and mechanisms of oncogenesis remain largely unknown. METHODS: Here we performed targeted next generation sequencing (NGS) on a pan-cancer gene panel in 15 ESC tumors to explore their genetic alterations, and aimed to identify clinically...
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