Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mixed ductal-lobular carcinoma: an analysis of CDH1 DNA copy number variation and mutation.

Breast cancer (Tokyo, Japan) - 1 Nov 2021

Tang Xiaoyan, Nakanishi Yoko, Kobayashi Hiroko, Nishimaki Haruna, Kusumi Yoshiaki, Miyagi Yohei, Masuda Shinobu

Abstract excerpt

BACKGROUND: Mixed ductal-lobular carcinoma (MDL) of the breast is poorly understood. Dysfunction of E-cadherin, a cell adhesion protein encoded by the CDH1 gene located on 16q22.1, causes loss of cell adhesion and cellular polarity in lobular carcinoma (LC). This study focuses the aberrations of CDH1 in LC, ductal carcinoma (DC), and MDL to investigate the pathogenesis of MDL. METHODS: The CDH1 DNA value (ratio...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antigens, CD
Share to Biomarkers, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms

Share to Cadherins

Share to Carcinoma, Intraductal, Noninfiltrating

Share to Carcinoma, Lobular

Share to DNA Copy Number Variations

Share to Mutation

Source

Identifiers

PMID: 34185256
DOI: 10.1007/s12282-021-01269-2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mixed ductal-lobular carcinoma: an analysis of CDH1 DNA copy number variation and mutation.PMID 34185256Read ↗

Phylogenetic analysis of combined lobular and ductal carcinoma of the breast.Semantic proximity Read ↗

Genomic and epigenomic basis of breast invasive lobular carcinomas lacking CDH1 genetic alterationsSemantic proximity Read ↗

ERBB2 mutation is associated with a worse prognosis in patients with CDH1 altered invasive lobular cancer of the breast.Semantic proximity Read ↗

Insights into E-Cadherin Impairment in CDH1-Unaltered Invasive Lobular Carcinoma: A Comprehensive Bioinformatic Study.Semantic proximity Read ↗

An Investigation Towards Understanding the Role of CDH1 Gene in Different Types of Breast CancersSemantic proximity Read ↗

E-cadherin immunohistochemical expression in invasive lobular carcinoma of the breast: correlation with morphology and CDH1 somatic alterations.Semantic proximity Read ↗

Mixed ductal-lobular carcinomas: evidence for progression from ductal to lobular morphology.Semantic proximity Read ↗

E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements.Semantic proximity Read ↗

Lobular breast cancer: incidence and genetic and non-genetic risk factors.Semantic proximity Read ↗

Clinicopathologic and genomic features of lobular like invasive mammary carcinoma: is it a distinct entity?Semantic proximity Read ↗

CDH1 germline mutations in families with hereditary lobular breast cancer.Semantic proximity Read ↗

Genomic Differences Between Pure Ductal Carcinoma In Situ of the Breast and that Associated with Invasive Disease: a Calibrated aCGH StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.