Article

SRSF2 is a key player in orchestrating the directional migration and differentiation of MyoD progenitors during skeletal muscle development

2024-04-08

Abstract excerpt

SRSF2 plays a dual role, functioning both as a transcriptional regulator and a key player in alternative splicing. The absence of SRSF2 in MyoD+ progenitors resulted in perinatal mortality in mice, accompanied by severe skeletal muscle defects. SRSF2 deficiency disrupts the directional migration of MyoD progenitors, causing them to disperse into both muscle and non-muscle regions. Single-cell RNA-sequencing analys...

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Literature Corpus work: 616d67da-4c7b-52cf-9ffa-02488872da8e
DOI: 10.1101/2024.04.06.588421

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