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Article

RBM4a-SRSF3-MAP4K4 Splicing Cascade Constitutes a Molecular Mechanism for Regulating Brown Adipogenesis.

International journal of molecular sciences - 6 Sept 2018

Peng Hui-Yu, Liang Yu-Chih, Tan Tse-Hua, Chuang Huai-Chia, Lin Ying-Ju, Lin Jung-Chun

Abstract excerpt

An increase in mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) reportedly attenuates insulin-mediated signaling which participates in the development of brown adipose tissues (BATs). Nevertheless, the effect of MAP4K4 on brown adipogenesis remains largely uncharacterized. In this study, results of a transcriptome analysis (also referred as RNA-sequencing) showed differential expressions of MAP4K4...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30200638
DOI: 10.3390/ijms19092646
PMCID: PMC6163301

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