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Article

Analysis of Paired Primary-Metastatic Hormone-Receptor Positive Breast Tumors (HRPBC) Uncovers Potential Novel Drivers of Hormonal Resistance.

PloS one - 1 Jan 2016

Manso Luis, Mourón Silvana, Tress Michael, Gómez-López Gonzalo, Morente Manuel, Ciruelos Eva, Rubio-Camarillo Miriam, Rodriguez-Peralto Jose Luis, Pujana Miguel A, Pisano David G, Quintela-Fandino Miguel

Abstract excerpt

We sought to identify genetic variants associated with disease relapse and failure to hormonal treatment in hormone-receptor positive breast cancer (HRPBC). We analyzed a series of HRPBC with distant relapse, by sequencing pairs (n = 11) of tumors (primary and metastases) at >800X. Comparative genomic hybridization was performed as well. Top hits, based on the frequency of alteration and severity of the changes,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27195705
DOI: 10.1371/journal.pone.0155840
PMCID: PMC4873174

Genes

EPHA7
MYC
DNAH5

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