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Article

Vocal and physical phenotypes of calsyntenin2 knockout mouse pups model early-life symptoms of the autism spectrum disorder.

Behavioural brain research - 27 Aug 2021

Klenova Anna V, Volodin Ilya A, Volodina Elena V, Ranneva Svetlana V, Amstislavskaya Tamara G, Lipina Tatiana V

Abstract excerpt

This study discovered a novel acoustic phenotype in Calsyntenin2 deficient knockout (Clstn2-KO) pups in the neurodevelopment period of 5-9 postnatal days (PND 5-9). The narrowband ultrasonic calls (nUSVs) were less complex (mostly one-note, shorter in duration and higher in peak frequency) in Clsnt2-KO than in wild-type (WT) C57BL/6 J pups. The wideband ultrasonic calls (wUSVs) were produced substantially more...

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PMID: 34182007
DOI: 10.1016/j.bbr.2021.113430

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