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Developing a multivariate prediction model of antibody features associated with protection of malaria-infected pregnant women from placental malaria

28 Jun 2021

Abstract excerpt

Background: -infected erythrocytes that express the parasite protein VAR2CSA on their surface can bind to placental chondroitin sulfate A. It has been hypothesized that naturally acquired antibodies towards VAR2CSA protect against placental infection, but it has proven difficult to identify robust antibody correlates of protection from disease. The objective of this study was to develop a prediction model using...

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PMID: 34181872
DOI: 10.7554/elife.65776

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