VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to<i>Plasmodium falciparum</i>Placental Malaria

doi:10.1093/infdis/jiw197

Article

VAR2CSA Domain-Specific Analysis of Naturally Acquired Functional Antibodies to<i>Plasmodium falciparum</i>Placental Malaria

18 May 2016

Abstract excerpt

BACKGROUND: Placental malaria is caused by Plasmodium falciparum-infected erythrocytes (IEs) that surface-express VAR2CSA and bind chondroitin sulfate A. The inflammatory response to placenta-sequestered parasites is associated with poor pregnancy outcomes, and protection may be mediated in part by VAR2CSA antibodies that block placental IE adhesion. METHODS: In this study, we used a new approach to assess...

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