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Functional Antibodies against Placental Malaria Parasites Are Variant Dependent and Differ by Geographic Region

12 Apr 2019

Abstract excerpt

During pregnancy, Plasmodium falciparum -infected erythrocytes (IE) accumulate in the intervillous spaces of the placenta by binding to chondroitin sulfate A (CSA) and elicit inflammatory responses that are associated with poor pregnancy outcomes. Primigravidae lack immunity to IE that sequester in the placenta and thus are susceptible to placental malaria (PM).

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PMID: 30988054
DOI: 10.1128/iai.00865-18

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