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Article

Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant Women

2 Feb 2006

Abstract excerpt

BACKGROUND: Pregnancy-associated malaria (PAM) is precipitated by the accumulation of parasites in the placental intervillous spaces and causes maternal anemia and low birth weight. In PAM, placental parasites adhere to chondroitin sulfate A (CSA) through a unique set of variant surface antigens (VSAPAM). Several studies have shown that 1 var gene, var2csa, is transcribed at high levels and expressed in...

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PMID: 16453268
DOI: 10.1086/500146

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Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamics of Anti‐VAR2CSA Immunoglobulin G Response in a Cohort of Senegalese Pregnant WomenPMID 16453268Read ↗

Evidence for the Involvement of VAR2CSA in Pregnancy-associated MalariaSemantic proximity Read ↗

Plasmodium falciparum population dynamics in a cohort of pregnant women in Senegal.Semantic proximity Read ↗

Effects of Sex, Parity, and Sequence Variation on Seroreactivity to Candidate Pregnancy Malaria Vaccine AntigensSemantic proximity Read ↗

Plasmodium falciparum VAR2CSA-Specific IgG Subclass Responses Reflect Protection Against Low Birth Weight and Pregnancy-Associated MalariaSemantic proximity Read ↗

High level of var2csa transcription by Plasmodium falciparum isolated from the placenta.Semantic proximity Read ↗

A single member of the Plasmodium falciparum var multigene family determines cytoadhesion to the placental receptor chondroitin sulphate A.Semantic proximity Read ↗

Positive selection of Plasmodium falciparum parasites with multiple var2csa-type PfEMP1 genes during the course of infection in pregnant women.Semantic proximity Read ↗

A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolatesSemantic proximity Read ↗

VAR2CSA Expression on the Surface of Placenta‐DerivedPlasmodium falciparum–Infected ErythrocytesSemantic proximity Read ↗

First-Trimester Plasmodium falciparum Infections Display a Typical “Placental” PhenotypeSemantic proximity Read ↗

Allelic variants of full-length VAR2CSA, the placental malaria vaccine candidate, differ in antigenicity and receptor binding affinitySemantic proximity Read ↗

Antibodies among Men and Children to Placental-Binding Plasmodium falciparum-Infected Erythrocytes that Express var2csaSemantic proximity Read ↗

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