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Vitamin D Receptor (VDR) Genetic Variants: Relationship of FokI Genotypes with VDR Expression and Clinical Disease Activity in Systemic Lupus Erythematosus Patients.

Genes - 3 Nov 2022

Meza-Meza Mónica R, Vizmanos Barbara, Rivera-Escoto Melissa, Ruiz-Ballesteros Adolfo I, Pesqueda-Cendejas Karen, Parra-Rojas Isela, Montoya-Buelna Margarita, Luquín Sonia, Campos-López Bertha, Mora-García Paulina E, Cerpa-Cruz Sergio, De la Cruz-Mosso Ulises

Abstract excerpt

Vitamin D (VD) deficiency is more frequent in systemic lupus erythematosus (SLE) patients than in control subjects (CS); genetic variants in the VD receptor (VDR) could contribute to the clinical disease activity. This study was aimed to determine the association of the VDR variants FokI (rs2228570), BsmI (rs1544410), ApaI (rs7975232), and TaqI (rs731236) with susceptibility to the disease, VD status, VDR mRNA...

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Topics

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Calcitriol
Case-Control Studies
Cross-Sectional Studies
Genetic Predisposition to Disease
Genotype
Lupus Erythematosus, Systemic
Receptors, Calcitriol
RNA, Messenger

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Identifiers

PMID: 36360253
DOI: 10.3390/genes13112016
PMCID: PMC9689830

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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