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Article

Insights into degradation mechanism of N-end rule substrates by p62/SQSTM1 autophagy adapter.

Nature communications - 17 Aug 2018

Kwon Do Hoon, Park Ok Hyun, Kim Leehyeon, Jung Yang Ouk, Park Yeonkyoung, Jeong Hyeongseop, Hyun Jaekyung, Kim Yoon Ki, Song Hyun Kyu

Abstract excerpt

p62/SQSTM1 is the key autophagy adapter protein and the hub of multi-cellular signaling. It was recently reported that autophagy and N-end rule pathways are linked via p62. However, the exact recognition mode of degrading substrates and regulation of p62 in the autophagic pathway remain unknown. Here, we present the complex structures between the ZZ-domain of p62 and various type-1 and type-2 N-degrons. The...

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Identifiers

PMID: 30120248
DOI: 10.1038/s41467-018-05825-x
PMCID: PMC6098011

Genes

SQSTM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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