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Article

The Proteomic Landscape of Growth Factor Signaling Networks Associated with FAT1 Mutations in Head and Neck Cancers.

Cancer research - 1 Sept 2021

Chen Zhengjia, Zhang Chao, Chen Jianhong, Wang Dongsheng, Tu Jieqi, Van Waes Carter, Saba Nabil F, Chen Zhuo G, Chen Zhong

Abstract excerpt

FAT1 is frequently mutated in head and neck squamous cell carcinoma (HNSCC), but the biological and clinical effects of FAT1 mutations in HNSCC remain to be fully elucidated. We investigated the landscape of altered protein and gene expression associated with FAT1 mutations and clinical outcomes of patients with HNSCC. FAT1 mutation was stratified with clinical information from The Cancer Genome Atlas HNSCC...

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Source

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Identifiers

PMID: 34167951
DOI: 10.1158/0008-5472.CAN-20-3659
PMCID: PMC8416803

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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