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Article

Comprehensive genomic characterization of head and neck squamous cell carcinomas.

Nature - 29 Jan 2015

Abstract excerpt

The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near...

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Topics

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Share to Carcinoma, Squamous Cell
Share to DNA Copy Number Variations
Share to DNA, Neoplasm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Head and Neck Neoplasms

Share to Molecular Targeted Therapy

Share to Oncogenes

Share to RNA, Neoplasm

Share to Squamous Cell Carcinoma of Head and Neck

Source

Open in PubMed Open full text

Identifiers

PMID: 25631445
DOI: 10.1038/nature14129
PMCID: PMC4311405

Genes

PIK3CA
TP53
AJUBA
CASP8
CDKN2A
E2F1
FAT1
HRAS
NFE2L2
NOTCH1
NSD1
TRAF3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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