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Article

FAT1 as a tumor mutation burden specific gene affects the immunotherapy effect in head and neck squamous cell cancer.

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Sept 2024

Cao Haotian, Lan Tianjun, Kuang Shijia, Wang Liansheng, Li Jintao, Li Qunxin, Li Yanyan, Xu Qiuping, Chen Qian, Ren Shuwei, Lan Chunhong, Ouyang Nengtai, Liao Jianwei, Huang Yongsheng, Li Jinsong

Abstract excerpt

BACKGROUND: Response to immunotherapy is the main challenge of head and neck squamous cancer (HNSCC) treatment. Previous studies have indicated that tumor mutational burden (TMB) is associated with prognosis, but it is not always a precise index. Hence, investigating specific genetic mutations and tumor microenvironment (TME) changes in TMB-high patients is essential for precision therapy of HNSCC. METHODS: A...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 38986165
DOI: 10.1016/j.drup.2024.101095

Genes

FAT1
AIRE
HOMER1
LRP1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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