Article
Inflammatory cytokines TNF-α and IL-17 enhance the efficacy of cystic fibrosis transmembrane conductance regulator modulators.
The Journal of clinical investigation - 16 Aug 2021
Rehman Tayyab, Karp Philip H, Tan Ping, Goodell Brian J, Pezzulo Alejandro A, Thurman Andrew L, Thornell Ian M, Durfey Samantha L, Duffey Michael E, Stoltz David A, McKone Edward F, Singh Pradeep K, Welsh Michael J
Abstract excerpt
Without cystic fibrosis transmembrane conductance regulator-mediated (CFTR-mediated) HCO3- secretion, airway epithelia of newborns with cystic fibrosis (CF) produce an abnormally acidic airway surface liquid (ASL), and the decreased pH impairs respiratory host defenses. However, within a few months of birth, ASL pH increases to match that in non-CF airways. Although the physiological basis for the increase is...
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