Article

An unexpected effect of TNF-α on F508del-CFTR maturation and function

2015-09-02

Abstract excerpt

Cystic fibrosis (CF) is a multifactorial disease caused by mutations in the cystic fibrosis transmembrane conductance regulator gene ( CFTR), which encodes a cAMP-dependent Cl - channel. The most frequent mutation, F508del, leads to the synthesis of a prematurely degraded, otherwise partially functional protein. CFTR is expressed in many epithelia, with major consequences in the airways of patients with CF, char...

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Literature Corpus work: 88baaac1-439e-566a-bed7-6ed190a83db7
DOI: 10.12688/f1000research.6683.2

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