Article

Putting Bicarbonate on the spot. Implication for theratyping in Cystic Fibrosis

2023-06-29

Abstract excerpt

Cystic fibrosis (CF) is caused by defective Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein. CFTR controls chloride (Cl - ) and bicarbonate (HCO 3 - ) transport into the Airway Surface Liquid (ASL).We investigated the impact of F508del-CFTR correction on HCO 3 - secretion by studying transepithelial HCO 3 - fluxes. HCO 3 - secretion was measured by pH-stat techniquein primary human respiratory e...

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Literature Corpus work: 4e35a594-22ce-5342-b3e2-a7cd5e7eebf0
DOI: 10.1101/2023.06.24.23291859

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