Article
Neonates with cystic fibrosis have a reduced nasal liquid pH; a small pilot study.
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society - 1 Jul 2014
Abou Alaiwa Mahmoud H, Beer Alison M, Pezzulo Alejandro A, Launspach Janice L, Horan Rebecca A, Stoltz David A, Starner Timothy D, Welsh Michael J, Zabner Joseph
Abstract excerpt
BACKGROUND: Disrupted HCO3(-) transport and reduced airway surface liquid (ASL) pH in cystic fibrosis (CF) may initiate airway disease. We hypothesized that ASL pH is reduced in neonates with CF. METHODS: In neonates with and without CF, we measured pH of nasal ASL. We also measured nasal pH in older children and adults. RESULTS: In neonates with CF, nasal ASL (pH5.2 ± 0.3) was more acidic than in non-CF neonates...
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