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Article

IL-17 family members exert an autocrine pro-inflammatory loop in CF respiratory epithelial cells ex vivo

17 Jan 2025

Abstract excerpt

Lungs of people with Cystic Fibrosis (pwCF) are characterized by chronic inflammation and infection with P. aeruginosa . High levels of IL-17 A and F have been observed in sputum of pwCF and the interleukin-17(IL-17) family (A-to-F) has been suggested to play a key role in CF pulmonary disease. We measured mRNA levels of IL-17 receptors (IL-17R) by RT-qPCR in CF bronchial epithelial (CFBE) cultured cells upon...

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PMID: 39837005
DOI: 10.1016/j.cellimm.2025.104926

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