Article
Diversity of Dominant Peripheral T Cell Receptor Clone and Soluble Immune Checkpoint Proteins Associated With Clinical Outcomes Following Immune Checkpoint Inhibitor Treatment in Advanced Cancers.
Frontiers in immunology - 1 Jan 2021
Li Ye, Wang Jiaqian, Wu Liangliang, Li Xiaoting, Zhang Xiaoyun, Zhang Guoqing, Xu Shengqiang, Sun Shengjie, Jiao Shunchang
Abstract excerpt
Dynamic changes of the peripheral T cell receptor (TCR) and soluble receptors and ligands (sRLs) have the potential to be used as biomarkers to monitor the evolution of the immune system in tumor patients undergoing immunotherapy. These functional biomarkers could be used to predict immune response to treatment with immune checkpoint inhibitors (ICIs) and to provide high-value information on the immune function...
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