Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cells

23 Jun 2021

Abstract excerpt

The polybromo-associated PBAF (SWI/SNF) chromatin remodeling complex, which includes PBRM1, ARID2, and BRD7, regulates cell differentiation and genomic integrity. MUC1-C is an oncogenic protein that drives lineage plasticity in prostate cancer (PC) progression. The present work demonstrates that MUC1-C induces PBRM1, ARID2, and BRD7 expression by the previously unrecognized E2F1-mediated activation of their...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Mechanisms and Therapy
Share to Chromatin Remodeling and Cancer
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 34163028
DOI: 10.1038/s41388-021-01899-y

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MUC1-C activates the PBAF chromatin remodeling complex in integrating redox balance with progression of human prostate cancer stem cellsPMID 34163028Read ↗

Dependence on MUC1-C in Progression of Neuroendocrine Prostate CancerSemantic proximity Read ↗

Complex-I Alteration and Enhanced Mitochondrial Fusion Are Associated With Prostate Cancer Progression.Semantic proximity Read ↗

Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancerSemantic proximity Read ↗

Identification of ferroptosis related genes and pathways in prostate cancer cells under erastin exposureSemantic proximity Read ↗

Glutamine transporters regulate prostate cancer radiosensitivity through NUPR1-mediated stress responseSemantic proximity Read ↗

Antioxidative stress protein SRXN1 can be used as a radiotherapy prognostic marker in prostate cancer patientsSemantic proximity Read ↗

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer.Semantic proximity Read ↗

BAF180: Its Roles in DNA Repair and Consequences in Cancer.Semantic proximity Read ↗

HSF1 is a novel prognostic biomarker in high-risk prostate cancer that correlates with ferroptosisSemantic proximity Read ↗

Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancerSemantic proximity Read ↗

FOXO1 inhibits prostate cancer cell proliferation via suppressing E2F1 activated NPRL2 expressionSemantic proximity Read ↗

PBRM1-Dependent PBAF Targeting is Required for EMT and Metastasis in Breast CancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.