Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer.

Cancer research - 15 Apr 2025

Zhang Chuanjie, Ding Jiawei, Lim Kiat Shenq, Zhou Wenjie, Miao Wenyu, Wu Siqi, Liu Hanqing, Huang Da, Chen Chufeng, He Hongchao, Xiao Jun, Xu Dan-Feng, Shen Yan, Huang Hai, Gao Yi

Abstract excerpt

Ferroptosis inducers have shown therapeutic potential in prostate cancer, but tumor heterogeneity poses a barrier to their efficacy. Distinguishing the regulators orchestrating metabolic cross-talk between cancer cells could shed light on therapeutic strategies to more robustly activate ferroptosis. In this study, we found that aberrant accumulation of Jumonji domain-containing 6 (JMJD6) proteins correlated with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Jumonji Domain-Containing Histone Demethylases
Share to Activating Transcription Factor 4

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ferroptosis

Share to Gene Expression Regulation, Neoplastic

Share to Glutathione

Share to Prostatic Neoplasms

Share to Repressor Proteins

Share to Xenograft Model Antitumor Assays

Source

Identifiers

PMID: 39903850
DOI: 10.1158/0008-5472.CAN-23-2796

Genes

JMJD6
SPOP
ATF4
GCLM
ME1
SLC7A11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

JMJD6 Rewires ATF4-Dependent Glutathione Metabolism to Confer Ferroptosis Resistance in SPOP-Mutated Prostate Cancer.PMID 39903850Read ↗

Divergent roles of SPOP and CHD1 in ACSL4 regulation reveal context-dependent vulnerabilities for targeting ferroptosis.Semantic proximity Read ↗

SPOP promotes ATF2 ubiquitination and degradation to suppress prostate cancer progressionSemantic proximity Read ↗

G3BP1 inhibits Cul3SPOP to amplify AR signaling and promote prostate cancer.Semantic proximity Read ↗

SPOP mutations promote p62/SQSTM1-dependent autophagy and Nrf2 activation in prostate cancer.Semantic proximity Read ↗

Identification of Ferroptosis-Associated Genes in Prostate Cancer by Bioinformatics AnalysisSemantic proximity Read ↗

Destruction of DDIT3/CHOP protein by wild-type SPOP but not prostate cancer-associated mutants.Semantic proximity Read ↗

Integrated Omics and Multicohort Analyses Identify an Enhancer Variant Linking Ferroptosis to Precision Therapy in Prostate Cancer.Semantic proximity Read ↗

Mitochondrial SLC25A10 promotes prostate cancer progression by inhibiting ferritinophagySemantic proximity Read ↗

SPOP Gene Mutations in Prostate Cancer: Deciphering Their Role in Disease Characterization and Targeted Interventions on AR SignalingSemantic proximity Read ↗

SPOP Mutations Target STING1 Signaling in Prostate Cancer and Create Therapeutic Vulnerabilities to PARP Inhibitor-Induced Growth Suppression.Semantic proximity Read ↗

Dual functions of SPOP and ERG dictate androgen therapy responses in prostate cancer.Semantic proximity Read ↗

LRP5 competes for SPOP binding to enhance tumorigenesis mediated by Daxx and PD-L1 in prostate cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.