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Article

Subtype-specific collaborative transcription factor networks are promoted by OCT4 in the progression of prostate cancer

18 Jun 2021

Abstract excerpt

Interactive networks of transcription factors (TFs) have critical roles in epigenetic and gene regulation for cancer progression. It is required to clarify underlying mechanisms for transcriptional activation through concerted efforts of TFs. Here, we show the essential role of disease phase-specific TF collaboration changes in advanced prostate cancer (PC). Investigation of the transcriptome in...

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PMID: 34145268
DOI: 10.1038/s41467-021-23974-4

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