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Article

Differences in microRNA-29 and Pro-fibrotic Gene Expression in Mouse and Human Hypertrophic Cardiomyopathy

17 Dec 2019

Abstract excerpt

Background: Hypertrophic cardiomyopathy (HCM) is characterized by myocyte hypertrophy and fibrosis. Studies in 2 mouse models (R92W-TnT/R403Q-MyHC) at early HCM stage revealed upregulation of endothelin (ET1) signaling in both mutants, but TGFβ signaling only in TnT mutants. Dysregulation of miR29 expression has been implicated in cardiac fibrosis. But it is unknown whether expression of miR29a/b/c and...

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PMID: 31921893
DOI: 10.3389/fcvm.2019.00170

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