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Article

Isogenic models of hypertrophic cardiomyopathy unveil differential phenotypes and mechanism-driven therapeutics.

Journal of molecular and cellular cardiology - 1 Aug 2020

Bhagwan Jamie R, Mosqueira Diogo, Chairez-Cantu Karolina, Mannhardt Ingra, Bodbin Sara E, Bakar Mine, Smith James G W, Denning Chris

Abstract excerpt

BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a prevalent and complex cardiovascular condition. Despite being strongly associated with genetic alterations, wide variation of disease penetrance, expressivity and hallmarks of progression complicate treatment. We aimed to characterize different human isogenic cellular models of HCM bearing patient-relevant mutations to clarify genetic causation and disease...

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Identifiers

PMID: 32531470
DOI: 10.1016/j.yjmcc.2020.06.003
PMCID: PMC7487780

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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