Article
Interleukin-6 is an activator of pituitary stem cells upon local damage, a competence quenched in the aging gland.
Proceedings of the National Academy of Sciences of the United States of America - 22 Jun 2021
Vennekens Annelies, Laporte Emma, Hermans Florian, Cox Benoit, Modave Elodie, Janiszewski Adrian, Nys Charlotte, Kobayashi Hiroto, Malengier-Devlies Bert, Chappell Joel, Matthys Patrick, Garcia Marie-Isabelle, Pasque Vincent, Lambrechts Diether, Vankelecom Hugo
Abstract excerpt
Stem cells in the adult pituitary are quiescent yet show acute activation upon tissue injury. The molecular mechanisms underlying this reaction are completely unknown. We applied single-cell transcriptomics to start unraveling the acute pituitary stem cell activation process as occurring upon targeted endocrine cell-ablation damage. This stem cell reaction was contrasted with the aging (middle-aged) pituitary,...
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