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Article

Decoding the activated stem cell phenotype of the neonatally maturing pituitary.

eLife - 14 Jun 2022

Laporte Emma, Hermans Florian, De Vriendt Silke, Vennekens Annelies, Lambrechts Diether, Nys Charlotte, Cox Benoit, Vankelecom Hugo

Abstract excerpt

The pituitary represents the endocrine master regulator. In mouse, the gland undergoes active maturation immediately after birth. Here, we in detail portrayed the stem cell compartment of neonatal pituitary. Single-cell RNA-sequencing pictured an active gland, revealing proliferative stem as well as hormonal (progenitor) cell populations. The stem cell pool displayed a hybrid epithelial/mesenchymal phenotype,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35699412
DOI: 10.7554/eLife.75742
PMCID: PMC9333987

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