Expression of a Testis-Specific Form of <i>Gal3st1</i> ( <i>CST</i> ), a Gene Essential for Spermatogenesis, Is Regulated by the <i>CTCF</i> Paralogous Gene <i>BORIS</i>

Abstract excerpt

Previously, it was shown that the CTCF paralogous gene, BORIS (brother of the regulator of imprinted sites) is expressed in male germ cells, but its function in spermatogenesis has not been defined. To develop an understanding of the functional activities of BORIS, we generated BORIS knockout (KO) mice. Mice homozygous for the null allele had a defect in spermatogenesis that resulted in small testes associated...

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