Article
Molecular determinants for α-tubulin methylation by SETD2.
The Journal of biological chemistry - 1 Jul 2021
Kearns Sarah, Mason Frank M, Rathmell W Kimryn, Park In Young, Walker Cheryl, Verhey Kristen J, Cianfrocco Michael A
Abstract excerpt
Post-translational modifications to tubulin are important for many microtubule-based functions inside cells. It was recently shown that methylation of tubulin by the histone methyltransferase SETD2 occurs on mitotic spindle microtubules during cell division, with its absence resulting in mitotic defects. However, the catalytic mechanism of methyl addition to tubulin is unclear. We used a truncated version of...
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