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Article

Mutations in SIRT2 deacetylase which regulate enzymatic activity but not its interaction with HDAC6 and tubulin.

Molecular and cellular biochemistry - 1 Sept 2007

Nahhas Fatimah, Dryden Sylvia C, Abrams Judith, Tainsky Michael A

Abstract excerpt

Human SIRT2 is a cytoplasmic NAD-dependent deacetylase implicated in the mitotic regulation of microtubule dynamics by its association with the class II histone deacetylase 6 (HDAC6). We have previously reported that SIRT2 is multiply phosphorylated in a cell cycle dependent pattern. Here, we dem...

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Source

Identifiers

PMID: 17516032
DOI: 10.1007/s11010-007-9478-6

Genes

SIRT2
HDAC6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17516032-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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