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Article

Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.

Nucleic acids research - 19 Jun 2020

Schellenberg Matthew J, Appel C Denise, Riccio Amanda A, Butler Logan R, Krahn Juno M, Liebermann Jenna A, Cortés-Ledesma Felipe, Williams R Scott

Abstract excerpt

Tyrosyl-DNA phosphodiesterase 2 (TDP2) reverses Topoisomerase 2 DNA-protein crosslinks (TOP2-DPCs) in a direct-reversal pathway licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOylation of TOP2. TDP2 also binds ubiquitin (Ub), but how Ub regulates TDP2 functions is unknown. Here, we show that TDP2 co-purifies with K63 and K27 poly-Ubiquitinated cellular proteins independently of, and separately from SUMOylated TOP2...

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Identifiers

PMID: 32356875
DOI: 10.1093/nar/gkaa318
PMCID: PMC7293035

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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