Article
Dido3 PHD modulates cell differentiation and division.
Cell reports - 11 Jul 2013
Gatchalian Jovylyn, Fütterer Agnes, Rothbart Scott B, Tong Qiong, Rincon-Arano Hector, Sánchez de Diego Ainhoa, Groudine Mark, Strahl Brian D, Martínez-A Carlos, van Wely Karel H M, Kutateladze Tatiana G
Abstract excerpt
Death Inducer Obliterator 3 (Dido3) is implicated in the maintenance of stem cell genomic stability and tumorigenesis. Here, we show that Dido3 regulates the expression of stemness genes in embryonic stem cells through its plant homeodomain (PHD) finger. Binding of Dido3 PHD to histone H3K4me3 is disrupted by threonine phosphorylation that triggers Dido3 translocation from chromatin to the mitotic spindle. The...
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