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Integrative Analysis of a Large Real-World Cohort of Small Cell Lung Cancer Identifies Distinct Genetic Subtypes and Insights into Histologic Transformation.

Cancer discovery - 7 Jul 2023

Sivakumar Smruthy, Moore Jay A, Montesion Meagan, Sharaf Radwa, Lin Douglas I, Colón Caterina I, Fleishmann Zoe, Ebot Ericka M, Newberg Justin Y, Mills Jennifer M, Hegde Priti S, Pan Quintin, Dowlati Afshin, Frampton Garrett M, Sage Julien, Lovly Christine M

Abstract excerpt

Small cell lung cancer (SCLC) is a recalcitrant neuroendocrine carcinoma with dismal survival outcomes. A major barrier in the field has been the relative paucity of human tumors studied. Here we provide an integrated analysis of 3,600 "real-world" SCLC cases. This large cohort allowed us to identify new recurrent alterations and genetic subtypes, including STK11-mutant tumors (1.7%) and TP53/RB1 wild-type tumors...

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Identifiers

PMID: 37062002
DOI: 10.1158/2159-8290.CD-22-0620
PMCID: PMC10326603

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