Article
O-glycoforms of polymeric immunoglobulin A1 in the plasma of patients with IgA nephropathy are associated with pathological phenotypes.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 31 Dec 2021
Yu Guizhen, Zhang Yong, Meng Bo, Xie Xinfang, Wang Zi, Ying Wantao, Lv Jicheng, Zhang Hong
Abstract excerpt
BACKGROUND: Immunoglobulin A1 (IgA1) O-glycosylation plays an important role in the pathogenesis of IgA nephropathy (IgAN). However, variations in IgA1 O-glycoforms have not been explored. We aimed to investigate the IgA1 O-glycoforms in the hinge region (HR) of polymeric IgA1 (pIgA1) and then evaluate the association between IgA1 O-glycoforms and crescent formation in IgAN. METHODS: The discovery cohort (Cohort...
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