Article
Relationship between immunoglobulin A1 lectin-binding specificities, mesangial C4d deposits and clinical phenotypes in immunoglobulin A nephropathy.
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association - 25 Jan 2022
Medrano Alfons Segarra, Muijsemberg Andrea, Wimbury David, Martin Marisa, Jatem Elias, González Jorge, Colás-Campás Laura, García-Carrasco Alicia, Martínez Cristina, Barratt Jonathan
Abstract excerpt
BACKGROUND: The reason why mesangial C4d deposits are detected in only certain biopsies of immunoglobulin A nephropathy (IGAN) remains unclear. We analyse the association between IgA glycosylation patterns, mesangial C4 deposition and clinical phenotypes in IgAN. METHODS: This cross-sectional study included 145 patients with idiopathic IgAN. We measured the serum levels of three different IgA1 lectin-binding...
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