The genetics and immunobiology of IgA nephropathy

doi:10.1172/jci74475

Article

The genetics and immunobiology of IgA nephropathy

2 Jun 2014

Abstract excerpt

IgA nephropathy (IgAN) represents the leading cause of kidney failure among East Asian populations and the most frequent form of primary glomerulonephritis among Europeans. Patients with IgAN develop characteristic IgA1-containing immune complexes that deposit in the glomerular mesangium, producing progressive kidney injury. Recent studies define IgAN as an autoimmune trait of complex architecture with a strong...

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