Article
IgA nephropathy.
Nature reviews. Disease primers - 11 Feb 2016
Lai Kar Neng, Tang Sydney C W, Schena Francesco Paolo, Novak Jan, Tomino Yasuhiko, Fogo Agnes B, Glassock Richard J
Abstract excerpt
Globally, IgA nephropathy (IgAN) is the most common primary glomerulonephritis that can progress to renal failure. The exact pathogenesis of IgAN is not well defined, but current biochemical and genetic data implicate overproduction of aberrantly glycosylated IgA1. These aberrant immunoglobulins are characterized by galactose deficiency of some hinge-region O-linked glycans. However, aberrant glycosylation alone...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.