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Article

A Standalone β-Ketoreductase Acts Concomitantly with Biosynthesis of the Antimycin Scaffold.

ACS chemical biology - 16 Jul 2021

Fazal Asif, Hemsworth Glyn R, Webb Michael E, Seipke Ryan F

Abstract excerpt

Antimycins are anticancer compounds produced by a hybrid nonribosomal peptide synthetase/polyketide synthase (NRPS/PKS) pathway. The biosynthesis of these compounds is well characterized, with the exception of the standalone β-ketoreductase enzyme AntM that is proposed to catalyze the reduction of the C8 carbonyl of the antimycin scaffold. Inactivation of antM and structural characterization suggested that rather...

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PMID: 34151573
DOI: 10.1021/acschembio.1c00229

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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