Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line.

Chembiochem : a European journal of chemical biology - 17 Oct 2011

Kusebauch Björn, Brendel Nicole, Kirchner Heike, Dahse Hans-Martin, Hertweck Christian

Abstract excerpt

Chain armor against tumor cells: The oxazole side chain in the antimitotic agent rhizoxin S2 (1) was successfully replaced through mutasynthesis by using an engineered mutant impaired in heterocyclization. Incorporation of 12 non-natural surrogates into fully processed rhizoxin analogues revealed a remarkable substrate flexibility of the PKS-NRPS hybrid.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibiotics, Antineoplastic
Share to Burkholderia
Share to Genes, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Loci

Share to Macrolides

Share to Oxazoles

Share to Peptide Synthases

Share to Polyketide Synthases

Source

Identifiers

PMID: 23106078
DOI: 10.1002/cbic.201100387

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Assessing oxazole bioisosteres as mutasynthons on the rhizoxin assembly line.PMID 23106078Read ↗

A Standalone β-Ketoreductase Acts Concomitantly with Biosynthesis of the Antimycin Scaffold.Semantic proximity Read ↗

Total synthesis approaches to natural product derivatives based on the combination of chemical synthesis and metabolic engineering.Semantic proximity Read ↗

New compounds by combining "modern" genomics and "old-fashioned" mutasynthesis.Semantic proximity Read ↗

Mutational biosynthesis--a tool for the generation of structural diversity in the biosynthesis of antibiotics.Semantic proximity Read ↗

Complexity‐to‐Diversity and Pseudo‐Natural Product Strategies as Powerful Platforms for Deciphering Next‐Generation TherapeuticsSemantic proximity Read ↗

The cryptophycins: Their synthesis and anticancer activitySemantic proximity Read ↗

Mutasynthesis - uniting chemistry and genetics for drug discovery.Semantic proximity Read ↗

First Ring-Expanded Maytansin Lactone Accessed by a New Mutasynthetic Variant.Semantic proximity Read ↗

Antimitotic Rhizoxin Derivatives from a Cultured Bacterial Endosymbiont of the Rice Pathogenic Fungus <i>Rhizopus</i> <i>m</i> <i>icrosporus</i>Semantic proximity Read ↗

Advanced mutasynthesis studies on the natural α-pyrone antibiotic myxopyronin from Myxococcus fulvus.Semantic proximity Read ↗

Malolactone strikes: K-Ras-G12D's Achilles' heel.Semantic proximity Read ↗

Disrupting linearity of PROTAC scaffolds prevents off-target complex I inhibitionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.