Article
Interferon-Gamma-Producing CD8+ Tissue Resident Memory T Cells Are a Targetable Hallmark of Immune Checkpoint Inhibitor-Colitis.
Gastroenterology - 1 Oct 2021
Sasson Sarah C, Slevin Stephanie M, Cheung Vincent T F, Nassiri Isar, Olsson-Brown Anna, Fryer Eve, Ferreira Ricardo C, Trzupek Dominik, Gupta Tarun, Al-Hillawi Lulia, Issaias Mari-Lenna, Easton Alistair, Campo Leticia, FitzPatrick Michael E B, Adams Joss, Chitnis Meenali, Protheroe Andrew, Tuthill Mark, Coupe Nicholas, Simmons Alison, Payne Miranda, Middleton Mark R, Travis Simon P L, Fairfax Benjamin P, Klenerman Paul, Brain Oliver
Abstract excerpt
BACKGROUND & AIMS: The pathogenesis of immune checkpoint inhibitor (ICI)-colitis remains incompletely understood. We sought to identify key cellular drivers of ICI-colitis and their similarities to idiopathic ulcerative colitis, and to determine potential novel therapeutic targets. METHODS: We used a cross-sectional approach to study patients with ICI-colitis, those receiving ICI without the development of...
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