Article

Microbiota-dependent expression of CTLA-4 by innate lymphoid cells restrains IFNγ dependent colitis

2023-03-27

Abstract excerpt

<title>Abstract</title> <p>The maintenance of intestinal homeostasis is a fundamental process critical for organismal integrity. Sitting at the interface of the gut microbiome and mucosal immunity, adaptive and innate lymphoid populations regulate the balance between commensal micro-organisms and pathogens. Checkpoint inhibitors (CPI), particularly those targeting the CTLA-4 pathway, disrupt this fine balance and...

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Literature Corpus work: 82f945d5-1f8d-5a37-81b2-8e1abac7f822
DOI: 10.21203/rs.3.rs-2729018/v1

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